WRONG concepts on Gender and Sex Science
An Analysis by M.Italiano

Comments on the article published at THE FEDERALIST,
by Stella Morabito and Joy Pullman


In a recent article (1) in the online news journal The Federalist, authors Stella Morabito and Joy Pullmann show their scientific illiteracy by spewing lots of erroneous information that is NOT scientific nor truthful about gender and sexual science.

Regardless of their political views or interests, there is no excuse for making up erroneous information or for at least not checking it out with scientists who know better before publishing such hogwash. As someone who has been mentored by Dr Elof Axel Carlson on the subject,

I think I know something about it and will spell out the wrong statements by Morabito and Pullmann using their statements after I make notation that they are WRONG and, in capitols, I will demonstrate the true, factual science with correct statements.

WRONG -"basic truth that all human beings, except the tiny percentage with genetic anomalies, have either XX or XY chromosomes imprinted on every single cell of their bodies."

CORRECT

MATURE RED BLOOD CELLS DO NOT HAVE A NUCLEUS AND THEREFORE DO NOT HAVE SEX CHROMOSOMES.
MATURE SPERM CELLS OF MEN WHO HAVE NO ABNORMALITIES DO NOT HAVE EITHER XX OR XY CHROMOSOMES.

INSTEAD THEY HAVE EITHER AN X OR A Y CHROMOSOME.
MORE IMPORTANTLY, HAVING XX OR XY CHROMOSOMES DOES NOT INDICATE SEX, SINCE MALES CAN BE XY OR XX (2) AND NORMAL FEMALES CAN BE XY OR XX (3). THE LATTER CONDITION (NORMALLY FERTILE FEMALES WITH A Y CHROMOSOME) MAY NOT BE A GENETIC ANOMALY BUT JUST A VARIATION. (3)

WRONG- "Gender is not assigned at birth, because a person’s sex is permanent. This is biology 101 that every school worth the name teaches at least in high school. And it means that gender is not assigned at birth, because a person’s sex is permanent. It’s inherent to each individual human from the first second that sperm and egg fuse. No amount of social shaming can change this basic fact of life."

CORRECT

GENDER AND SEX ARE ASSIGNED AT BIRTH BASED UPON GENITAL APPEARANCE.

FROM THE FIRST SECOND THAT THE SPERM AND EGG FUSE, SEX IS NEITHER INHERENT NOR PERMANENT. EVEN THE CHROMOSOME CONSTITUTION IS NOT INHERENT DURING FUSION SINCE THE MIXING OF THE GENETIC MATERIAL, A PROCESS KNOWN AS SYNGAMY, DOES NOT OCCUR UNTIL LATER.
ADDITIONALLY, CHROMOSOMAL CONSTITUTION IS NOT ESTABLISHED AT FUSION (OR FERTILIZATION) BECAUSE POLAR BODY EXTRUSION NEEDS TO OCCUR.
CHROMOSOME CONSTITUTION IS ALSO NOT PERMANENT SINCE DURING EMBRYOGENESIS MITOTIC NON-DISJUNCTION CAN OCCUR AFTER FUSION AND AFTER FERTILIZATION-

SOMETIMES LONG AFTER. THIS NON-DISJUNCTION CAN CHANGE A NORMAL PERSON INTO A PERSON WITH ASPECTS OF BOTH SEXES OR FOR THE CASE OF DOUBLE NON-DISJUNCTION CAN TOTALLY CHANGE THE SEX.
THUS SEX IS NOT PERMANENT. A SECOND EXAMPLE OF HOW "SEX IS NOT PERMAMENT SINCE THE FIRST SECOND THAT THE SPERM AND EGG FUSE", IS THAT EVEN CHROMOSOMALLY,
TWIN EMBRYOS OF OPPOSITE SEXES CAN MELD AND EACH NORMAL TWIN CAN BECOME ONE SINGLE HERMAPHRODITE PERSON (CHIMERISM).
THIRD, SEX IS NOT INHERENT OR PERMANENT AT FUSION BECAUSE REGARDLESS OF CHROMOSOME CONSTITUTION, THE EMBRYO WILL BECOME FEMALE UNLESS VARIOUS TYPES OF MALE PROTEINS AND HORMONES ARE NOT ONLY PRODUCED BUT ALSO BOUND.

THUS, CONTRARY TO THE AUTHORS' CLAIMS, SEX IS NOT INHERENT NOR PERMANENT "THE FIRST SECOND THAT SPERM AND EGG FUSE" BECAUSE A NORMAL PERSON CAN OBTAIN ASPECTS OF BOTH SEXES IF THEY ARE HORMONALLY INFLUENCED BY MANY FACTORS INCLUDING A TWIN.

A FOURTH EXAMPLE, THAT EVEN CHROMOSOMES ARE NOT PERMANENT, IS THAT EVEN A NORMAL PERSON CAN BECOME CHROMOSOMALLY MIXED WITH CELL TYPES TYPICAL OF BOTH NORMAL MALES AND NORMAL FEMALE AFTER BONE MARROW TRANSPLANTS (4, 5).
SOME CASES OF PERSONS THOUGHT TO HAVE BEEN BORN WITH A MIXTURE OF CHROMOSOMES USUALLY FOUND FOR MALES AND FEMALES WERE CASES WHERE THE PERSON BECAME CHROMOSOMALLY A MIX OF CHROMOSOMES TYPICAL FOR BOTH MALES AND FEMALES DUE TO A BONE MARROW TRANSPLANT THAT WAS ACQUIRED (6, 7).
THUS, DESPITE THE AUTHORS' ERRONEOUS STATEMENTS TO THE CONTRARY,
THE BODY WILL BE ABLE TO BE TRANSMOGRIFIED, EVEN CHROMOSOMALLY, TO INCLUDE ASPECTS OF BOTH SEXES AND THIS RESULT CAN BE EVEN CHROMOSOMALLY INDISTINGUISHABLE FROM A BORN GENETIC ANOMALY AFTER THE PERSON HAS A GONADECTOMY SINCE THE ONLY CELLS WHICH HAVE NOT SHOWN TO BE CHANGED IN BONE MARROW RECIPIENTS ARE NORMAL GONADAL GERM (EG., SPERM) CELLS WHICH ARE REMOVED AT GONADECTOMY.
THE MIXTURE OFTEN CAN OCCUR IN 100% OF BLOOD CELLS (WHICH MAKES UP 1/4 OF BODILY CELLS), AND IN VARYING CELLULAR RATIOS OF OTHER BODILY TISSUES SUCH AS SKIN, FINGERNAILS, HAIR, BUCCAL TISSUE, BONE, BRAIN, LIVER AND SO ON (8).
THE CELLS ARE NOT MERELY JUST HOSTS OF THE RECIPIENT, BUT ACTUALLY BECOME FUNCTIONAL CELLS OF THE RECIPIENT (9). THE MECHANISM NEED NOT MERELY BE THE ADDITION OF A DONOR KARYOTYPE BUT THE BMT PROCESS ITSELF CAN KNOCK OUT THE Y CHROMOSOME OF THE RECIPIENT (4).
THIS IS NOT IRRELEVANT FOR TRANSSEXUALS SINCE AN EXAMPLE DANIELLE ARRINI, WHO HAD A BONE MARROW TRANSPLANT, WAS RECENTLY DISCUSSED WITH REGARD TO THE TRANS BATHROOM ISSUE (10). CHROMOSOME TESTING COULD SEND THE PERSON TO THE WOMEN'S ROOM REGARDLESS OF WHETHER ANY TREATMENT TYPICAL FOR TRANSITION WAS GIVEN AND IT COULD SEND A NON-TRANSSEXUAL NORMAL MAN THERE ALSO.

WRONG- "There is no logic to implementing the transgender agenda, because it inherently requires irrationally rejecting the simple, biological reality that men and women’s bodies are quite different, and that nothing can make a genetically normal person transmogrify either into the other sex or into the very small number of people whose bodies, due to genetic defects, include aspects of both sexes."

CORRECT

A GENETICALLY NORMAL PERSON AND A GENETICALLY ABNORMAL PERSON CAN INDEED TRANSMOGRIFY INTO THE OTHER MORPHOLOGIC SEX.
THERE ARE PLENTY OF CASES WHERE THE INDIVIDUAL'S CHROMOSOMAL TYPE DOES NOT MATCH THEIR SEXUAL MORPHOLOGY.
FURTHER, A GENETICALLY NORMAL PERSON INDEED CAN TRANSMOGRIFY INTO THE VERY SMALL NUMBER OF PEOPLE WHOSE BODIES, DUE TO GENETIC DEFECTS, INCLUDE ASPECTS OF BOTH SEXES.
BONE MARROW TRANSPLANTS WILL ACHIEVE THIS BY TRANSMOGRIFYING THE CHROMOSOMES FROM THAT OF A NORMAL PERSON TO THAT TYPICALLY FOUND FOR A GENETICALLY INTERSEXED/DUAL SEXED (CHIMERIC) PERSON. FINALLY, SEX ASSIGNMENT/REASSIGNMENT PROCEDURES WILL
TRANSMOGRIFY A GENETICALLY NORMAL PERSON INTO A PERSON WHO INCLUDES ASPECTS OF BOTH SEXES JUST AS EFFECTIVELY AS SOMEONE WHO WAS BORN GENETICALLY NORMAL BUT WHO HAD ASPECTS OF BOTH SEXES DUE TO NON-GENETIC (EG., ENVIORNMENTAL) ANOMALIES AS THERE ARE PLENTY OF PEOPLE WHOSE SEX CONTAINS ASPECTS OF BOTH SEXES DUE NOT TO GENETIC CAUSES BUT TO ENVIRONMENTAL CAUSES.
PERSONS WITH PENILE ABLATIO OR TRANSSEXUAL PERSONS CAN BE JUST LIKE THOSE INTERSEXED CASES-EACH OF WHICH LEAVES NO GENETIC TRACE, SINCE THE CAUSE IS NON-GENETIC BUT INSTEAD IS ENVIRONMENTAL (EG., TOXIN, POLLUTANT, IATROGENIC).

THUS, THE FEDERALIST ARTICLE DOES NOT HAVE THE SCIENTIFIC REALITY ON GENDER OR SEX.



REFERENCES

1) http://thefederalist.com/2016/02/23/the-transgender-war-against-human-rights-science-and-consent/

2) Rajender S1, Rajani V, Gupta NJ, Chakravarty B, Singh L, Thangaraj K SRY-negative 46,XX male with normal genitals, complete masculinization and infertility. Mol Hum Reprod. 2006 May;12(5):341-6.

3) Italiano, MA (2008) Fertile XY females. Journal of Clinical Endocrinology & Metabolism. http://press.endocrine.org/e-letters/10.1210/jc.2007-2155

4)Imahashi N, Ohashi H, Arito K et al. Acute Lymphoblastic Leukemia of male-recipient origin demonstrating female karyotype after cord blood transplantation. Journal of Clinical Oncology. 2010; 28(36):e750-e752.

5) http://discovermagazine.com/2008/apr/09-the-man-who-lost-his-name-and-his-genetic-identity

6) Nebesion TD, Torres-Martinez, W, Rink, RC, Eugster, EA. Spurious case of XX maleness in a patient with a history of Wiskott-Aldrich Syndrome. Endocrine Practice. 2011;17(2):e1-e3.

7) http://ijcci.info/issue-index/volume-3-issue-4/132-case-report/169-xy-femaleness-in-a-patient-with-aplastic-anemia

8) Krause DS. Plasticity of marrow-derived stem cells. Gene Therapy. 2002; June 9 (11):754-758.1

9) Taylor HS. Endometrial cells derived from donor stem cells in bone marrow transplant recipients. JAMA. 2004 Jul 7;292(1):81-5

10) http://guidetravel.biz/oman/seattles-absurd-discriminatory-trans-bathroom-panic-106570.html


Writer-Dr M Italiano, Scientific Director of the Organisation Intersex International (OII) has been a licensed physician (India) and has an avid interest in intersex issues, stem cells, and holistic medicine.

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